Dr. Barclay-White is a Principal Investigator in the FROST (Freezing Alone Instead of Resection Of Small Tumors) clinical trial, sponsored by Sanarus. This is a national study of the use of cryoablation in management of early-stage breast cancer. Women who meet the following criteria may be eligible to participate:

• Age 50 years or older
• Have had a needle biopsy of the cancer showing Invasive Ductal Carcinoma
• Have had a needle biopsy of the cancer showing it is estrogen sensitive
• Have cancer that is visible by ultrasound
• Have cancer that measures 2.0 cm or less by mammogram, ultrasound and MRI
• Be physcially and emotionally able to complete follow-up biopsy, MRIs, endocrine therapy and/or radiation (radiation is required for participants age 50-69).